@article{ACS16872,
author = {Gérald Simonneau and Peter Dorfmüller and Christophe Guignabert and Olaf Mercier and Marc Humbert},
title = {Chronic thromboembolic pulmonary hypertension: the magic of pathophysiology},
journal = {Annals of Cardiothoracic Surgery},
volume = {11},
number = {2},
year = {2021},
keywords = {},
abstract = {Chronic thromboembolic pulmonary hypertension (CTEPH) is a rare and underdiagnosed complication of acute pulmonary embolism (APE). CTEPH is a common cause of pulmonary hypertension (PH) with distinct management strategy including pulmonary endarterectomy, balloon pulmonary angioplasty, long-term anticoagulation and PH drugs targeting endothelial cell dysfunction. Initially, PH in chronic thromboembolic pulmonary disease (CTEPD) was thought to be due exclusively to the intravascular obstruction of pulmonary arteries by unresolved fibrotic clots. However, it is now well accepted that pulmonary vascular remodelling can include significant pulmonary microvasculopathy, which plays a role in the development of CTEPH. The histological description and clinical consequences of CTEPH microvasculopathy are now better understood. These lesions may involve not only small muscular pulmonary arteries },
issn = {2304-1021}, url = {https://www.annalscts.com/article/view/16872}
}