@article{ACS16864,
author = {Zachary A. Spigel and Iki Adachi and Ziyad M. Binsalamah and Dhaval Parekh and Athar M. Qureshi},
title = {Transcatheter pulmonic valve implantation in adult patients with prior congenital heart surgery},
journal = {Annals of Cardiothoracic Surgery},
volume = {10},
number = {5},
year = {2021},
keywords = {},
abstract = {Background: Transcatheter pulmonary valve replacement (TPVR) is now an established modality for pulmonary valve replacement in suitable candidates. We aim to describe our experience with TPVR in adults.
Methods: This is a descriptive study of all TPVR performed in adults with congenital heart disease at a single institution from 2010–2020. All adult patients (defined as 18 years old or older at TPVR) were included. Time-to-event outcomes were described using Kaplan-Meier estimates with 95% confidence intervals (CIs).
Results: Out of a total of 200 patients that had undergone TPVR, 81 patients (57% male) met the inclusion criteria, with a median age and weight of 26 years (IQR 21–37) and 71.0 kg (IQR 54.6–89.0), respectively. In the cohort, 45 (56%) patients had tetralogy of Fallot. While 53 (65%) patients received a Melody valve, a Sapien valve (S3 in 20, XT in eight) was implanted in the rest. Pre-stenting was performed in 49 (52%) patients. One patient died of severe heart failure a year following TPVR. One patient had a second TPVR performed 2.2 years following initial TPVR for severe pulmonary regurgitation. Valve survival at 2.2 years was 94% (95% CI: 87–100%). Four patients developed endocarditis. Endocarditis-free survival was 89% (95% CI: 80–100%) at three years.
Conclusions: Our experience suggests favorable results of TPVR in adults with congenital heart disease. Additional research would be warranted with a focus on total valve longevity and patient reported outcomes, in order to improve the understanding of TPVR in this population and further refine this technology.},
issn = {2304-1021}, url = {https://www.annalscts.com/article/view/16864}
}