@article{ACS16664,
author = {Khalil Jawad and Guenther Kroeg and Alex Koziarz and Sven Lehmann and Maja Dieterlen and Stefan Feder and Jens Garbade and Vivek Rao and Michael Borger and Martin Misfeld},
title = {Surgical options in infective valve endocarditis with neurological complications},
journal = {Annals of Cardiothoracic Surgery},
volume = {8},
number = {6},
year = {2019},
keywords = {},
abstract = {Background: Surgery is a common treatment option for patients with infective endocarditis. We present a large cohort of surgically managed patients with infective endocarditis and evaluate the long-term mortality of those with and without neurological complications.
Methods: We performed a retrospective review of patients surgically managed for infective endocarditis between 1994 and 2017. Demographic and outcome data were collected using a hospital database. Time-to-event analysis was performed with Kaplan-Meier curve and compared statistically with log-rank testing.
Results: At the time of admission, 680 (27.7%) patients with infective endocarditis showed neurological complications. The mean age was 62.6±14.0 years and 70% were male. Two thousand two hundred and sixty-one (92%) patients had left-sided valve endocarditis. Isolated aortic valve endocarditis was present in 59% of patients and 35% of patients had isolated infective endocarditis of the mitral valve. Mean logistic EuroSCORE was 21.2±21.6. Microbiologic cultures were positive in 1,939 patients (79%). The most common bacteria were Staphylococcus aureus (26%). In-hospital mortality in the group of patients with Staphylococcus aureus was significantly higher than in the group infected with other pathogens (18.2% vs. 13.4%, P=0.004). Patients with vegetations ≥1 cm had significantly more systemic embolization (P},
issn = {2304-1021}, url = {https://www.annalscts.com/article/view/16664}
}