Extracorporeal membrane oxygenation for accidental deep hypothermia—current challenges and future perspectives

Introduction

Accidental hypothermia (core temperature ≤35 °C) is a deleterious condition carrying a high risk of mortality which, with appropriate measures, can be successfully treated (1). In the United States alone, accidental hypothermia causes almost 1,500 deaths annually (1). Although accidental hypothermia as a medical condition displays a tendency to occur in colder climates, with many reports coming from northern countries such as Norway (2,3), Canada (4); Alpine regions of Switzerland (5), Austria (6) or France (7); and regions at lower altitudes with a moderate climate, such as The Netherlands (8), Poland (9), France (10), Austria (Lower Austria) (11), Denmark (12) or Japan (13), it is not confined to any geographical area, as evidenced by cases reported even from Australia (14).

The incidence of accidental hypothermia appears to be underestimated, mainly due to diagnostic problems. Although the gold standard is to measure the patient’s core temperature, such measurement is difficult to conduct during rescue operations. In the prehospital setting, a clinical staging scheme (Swiss Staging System; HT) is employed (1). Based on recent recommendations, hypothermic patients with cardiac instability at stage HT III (core body temperature <28 °C) and HT IV (hypothermic cardiac arrest) are candidates for rewarming using extracorporeal life support (ECLS) with cardiopulmonary bypass (CPB) or extracorporeal membrane oxygenation (ECMO) (1,15-17).

The first reports on the use of CPB for extracorporeal rewarming in accidental hypothermia date back to 1967 (18). Successful ECLS-aided rewarming has been reported from temperatures as low as 13.7 °C (CPB) (19), and a period as long as 6 h 45 min after hypothermic cardiac arrest (with ventricular fibrillation) (ECMO) (20). Today, a growing body of evidence supports the notion that ECMO in its veno-arterial (VA) configuration is a better treatment for hypothermic, unstable or arrested patients (21). An increasing number of institutions consider VA-ECMO as the first-line of treatment due to the possibility of prolonged support and a decreased incidence of severe cardiorespiratory instability (22,23), also in the pediatric population (24).

The patient spectrum will differ from institution to institution, however, making the population very inhomogeneous. Depending on the location of the reporting hospital, therefore, the majority of patients may be avalanche victims or mountaineers (5,6)—mostly fairly young, with no significant underlying medical problems, but with potential trauma and asphyxiation; patients from urban populations (8,10,11,13)—often intoxicated, frequently suffering from comorbidities; or drowning victims (10,12)—at a high risk of primary asphyxia. The outcomes in these populations are varied. The authors represent a Severe Hypothermia Treatment Center (22), which, due to its geographical location, manages a variety of hypothermic patients, ranging from urban cases, through drowning victims, to mountain accident victims.

Guidelines and coordination

The specificity of accidental hypothermia management is that it always takes place in an acute setting. Due to a paucity of data—virtually no randomized trials have been conducted to date—strong evidence endorsing any strategy is lacking, although the general consensus is that ECLS is the gold standard in hypothermic patients with cardiac arrest (16), with VA-ECMO being the preferred method due to its rapid availability, lower heparinization requirement (as compared with CPB), and possibility of prolonged support (15). Several algorithms have been developed that mandate the use of ECLS for rewarming, including the Bernese Hypothermia Algorithm (5) and the algorithm endorsed by the International Commission for Mountain Emergency Medicine (15). ECLS is indicated in HT IV and HT III in unstable non-arrested patients (understood as those presenting with life-threatening arrhythmia, hypotension with a systolic blood pressure of <90 mmHg, respiratory failure or refractory acidosis) (15). The coordination of the rescue effort and arrangement of the rewarming procedure is complex, and usually rests on the intensivist/anesthesiologist or emergency physician. In the context of the complexity of the whole process (e.g., coordination of mountain rescue services; emergency medical services with an automated chest compression device; ground and/or air transportation; and, finally, operating room personnel with cardiac surgeons or an out-reach ECMO team) the existence of accidental hypothermia treatment centers and coordinators seems reasonable in high prevalence areas.

Many cases are likely mistreated worldwide due to a lack of information, coordination and cooperation. Higher-level regulations in this regard are urgently needed—the ECLS management of severe accidental hypothermia should be regulated (and funded) on a national governmental level. A hypothermia coordinator, who is trained in decision making, may support physicians treating hypothermic patients and help in deciding whether ECLS is indicated (9). Decision-making is oftentimes difficult, based on fragmented data, while our clinical practice shows that there are very few straightforward cases. Apart from the fact that the clinical presentation of severe hypothermia is difficult to distinguish from the clinical signs of death (posing a problem for prehospital services who have not been trained), patients often present complex cases (e.g., trauma and asphyxiation in avalanche victims or intoxication and underlying conditions in urban cases). What is more, there may be a need for the simultaneous ECLS treatment of multiple patients (12), where inter-institutional coordination is crucial. In this perspective article, we discuss pertinent procedural and post-procedural issues in ECMO therapy in hypothermic subjects. We also discuss current outcomes of extracorporeal resuscitation in severe hypothermia and outline the important research goals to improve them.

Technical and practical considerations

VA-ECMO offers cardiac support, enabling treatment of arrested patients, with the highest achievable rewarming rate (up to 6 °C/h) and a wide flow span (1). There are significant differences in rewarming strategies among reports, while the optimal speed of rewarming and ECLS flow are still to be established. Animal studies on a porcine model of accidental deep hypothermia with cardiac arrest revealed that low ECLS flow does not attenuate post-rewarming pulmonary lesions, but decreases cardiac output (25). On the other hand, also in a porcine model, it has been shown that a high temperature delta between the core temperature and ECLS increases lung injury (26). A recent analysis by Saczkowski et al. revealed that a slower rate of ECLS rewarming is independently associated with an improved neurologic outcome (23). This is in line with what we know about rewarming from hypothermia during cardiac surgery (27).

On the other hand, it should be pointed out that in cardiac arrest or severe cardiorespiratory insufficiency, the priority is to move the patient out of the danger zone (below 28–30 °C) as quickly as possible. In this range of core temperatures, the risk of spontaneous or iatrogenic VF is very high. Moreover, we do not know whether different types of hypothermia (acute, urban) require similar or different rewarming strategies. Future research should also answer the burning question of whether a patient suffering from cardiac arrest due to accidental hypothermia should be managed with mild therapeutic hypothermia in the post-resuscitation period of ECMO as well. Severe peripheral complications can complicate ECMO when femoral access is used, with up to 20% of patients suffering from limb ischemia (4,28). Although the use of distal perfusion cannulas is routine, implantation during cardiopulmonary resuscitation (CPR) in an arrested patient may be, and often is, challenging. Furthermore, in some ECMO centers, percutaneous ultrasound-guided placement of the arterial and venous cannulas is preferred (10). It is difficult to achieve adequate peripheral perfusion with this technique.

There is a need for new cannulas that permit parallel retrograde flow, enabling continuous peripheral extremity perfusion. Currently, new and virtually wall-less arterial cannulas are being studied that maintain bidirectional flow (29). Although such an approach would also simplify the circuit and the implantation procedure, their feasibility during CPR implantation in hypothermia is unknown. Our strategy is to bring the patient to the operating room and perform the procedure surgically, with as much asepticity as possible, even if the patient is in an extremely disheveled state. As ECMO therapy increases the risk of sepsis substantially (30), even if the implantation is elective, all efforts should be made to minimize this risk in the acute setting. The Bernese group suggest that in patients with suspected trauma, a focused assessment with sonography in trauma (FAST) should be performed simultaneously with the establishment of femoral access (5). Although better strategies in patients with suspected trauma are as yet unknown, a CT trauma scan prior to the onset of ECMO installation still seems a reasonable course of action. The major concern in extracorporeal rewarming in patients with traumatic injuries is the risk of heparinization-related bleeding.

It should be highlighted, however, that even severe poly-trauma seems not to be an absolute contraindication for ECLS-aided rewarming, as commonly believed. The heparin-coated circuits offer supplemental cardiopulmonary support for selected massively injured patients, both during CPR and while their primary injuries are being evaluated and treated (31,32). On the other hand, a French group recently reported that ECMO implantation is already feasible during out-of-hospital CPR for refractory cardiac arrest, thus on-site (33). Another problem often met in severe hypothermic patients is volume depletion and the need for aggressive fluid replacement in order to maintain sufficient ECLS inflow. Unfortunately, microcirculatory derangement and diffuse endothelial damage “open the door” to extravasation and massive tissue edema that would necessitate emergency fasciotomies, laparotomies and/or drainage to treat compartment syndromes. In addition, acute renal failure as a direct consequence of volume depletion and intraabdominal compartment syndrome is often seen in the post-resuscitation phase and requires renal replacement therapy.

Post-rewarming issues

Patients who have been successfully rewarmed still constitute a challenging group. Although a good proportion of hypothermic subjects treated with ECLS present good neurologic outcomes [Cerebral Performance Category (CPC) 1 or 2] (23), virtually all patients require attentive rehabilitation care while some will never recover fully. Thus, any ECMO center should be prepared for intensive early rehabilitation and be able to discharge the patient to a rehabilitation facility where the required skills are available. In some cases of urban hypothermia, physicians will face successfully rescued individuals with substance abuse issues, those who are homeless, and lack social support. Social services should participate in the management of such patients in order to obtain a good recovery, as well as solve reimbursement issues for those uninsured. Furthermore, some individuals will suffer from associated wound issues, not directly associated with ECLS (i.e., frostbite, ulcers etc.). Although the management of these problems is complicated and cost-consuming, they should be anticipated and considered beforehand. Despite the cost of ECMO rewarming and subsequent ICU stays being high, this was reported to be lower than in ECMO for other indications and intensive care treatment for other causes (34). Moreover, many rewarmed patients with good neurologic outcomes return to their vocational activity and social life, reducing the social burden of accidental hypothermia.

Outcomes and prognostication

The outcomes of ECMO treatment for severe accidental hypothermia with hemodynamic instability or cardiac arrest are encouraging to the point where the authors would suggest that any cardiac center equipped with ECMO should be involved in an ECLS hypothermia treatment program. A recent analysis of 44 observational studies and 40 case reports by Saczkowski et al. (23), comprising 658 patients with accidental hypothermia treated with ECLS, revealed an overall survival rate with a good neurologic outcome of 40.3% (23). This study indicated a higher rewarming rate, asphyxiation, and a higher serum potassium level as the negative independent predictors of good neurologic outcome, while the female gender seemed to be protective (23). The last factor is in striking alignment with the outcomes of the Præstø Fjord boating accident which occurred in Denmark in 2011 (12). Our data on 29 patients treated with VA ECMO in severe hypothermia (HT III and IV) revealed one-year survival of 45% (most patients with CPC 1) (34).

Notwithstanding, it is rather difficult to predict which patient will present with a favorable outcome, and in whom the treatment is futile. Most studies report high potassium levels (>12 mmol/L in accidental hypothermia and >8 mmol/L for hypothermia due to avalanche burial) as a predictor of poor outcome (35). A recent publication by Pasquier et al. presented the first outcome prediction tool for ECLS-treated patients with hypothermic cardiac arrest (“The HOPE score”, developed based on international data from 286 patients) (35). The calculator (available online at: www.hypothermiascore.org) estimates one’s chance of survival, considering age, gender, asphyxia, CPR duration, serum potassium level and temperature (35). Further answers with regard to outcome prediction are likely to be yielded by the International Hypothermia Registry (www.hypothermia-registry.org), in which the data of patients with accidental hypothermia are collected.

Perspectives and research goals

Hypothermia is associated with substantial fluid shifts with microvascular extravasation. Although hemodilution with ECMO may be beneficial, it is unknown whether different types of priming solutions may modulate the outcomes. While cerebral edema is a major concern, the effect of priming solution composition (crystalloids vs. colloids) has not been studied in subjects suffering from accidental hypothermia. A future goal is also the development of an ECMO circuit that would be easy to prime (a pre-prepared set with a one-click-to-prime type of technological solution), fail-safe and requiring no heparinization, in order that it could be easily set up and started in the setting of emergency department, without the need of perfusionist in attendance, with the aim of shortening the door-to-ECMO time, e.g., in cases of hypothermic cardiac arrest. New technologies are needed to extend the possible ECMO treatment duration with coated circuits, when no heparin is administered. On the other hand, considering the fact that a substantial subset of hypothermic patients may represent moribund trauma patients, circuits made with new materials that would be entirely anticoagulation-free should be developed. Nevertheless, even if ECMO is implanted in the emergency room, or even on-site (33) by an out-reach team, such patients should ideally be managed in the cardiac ICU of a multidisciplinary referral hospital.

Conclusions

Further studies are needed in order to provide evidence-based protocols for extracorporeal rewarming techniques in severe accidental hypothermia. Outcomes, however, are already very favorable, even in patients with even long resuscitation times for hypothermic cardiac arrest, thereby justifying the statement that every cardiac surgery center should be ready and available for ECLS rewarming in accidental deep hypothermia.

Acknowledgements

Funding: This study was funded by a grant from the Jagiellonian University, Cracow, Poland (No. K/ZDS/007961 to P Mazur).

Footnote

Conflicts of Interest: The authors have no conflicts of interest to declare.

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